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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 3
2000 4
2001 13
2002 19
2003 38
2004 43
2005 28
2006 24
2007 2
2008 7
2009 8
2010 7
2011 10
2012 22
2013 18
2014 15
2015 20
2016 16
2017 25
2018 30
2019 39
2020 34
2021 45
2022 17
2023 8
2024 2

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443 results

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Page 1
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation.
Zhang XW, Zhou JC, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, Wang F, Jin CC, Yang ZN, Zhao CX, Hou XY, Huang B, Hu ZW. Zhang XW, et al. Autophagy. 2020 May;16(5):782-796. doi: 10.1080/15548627.2019.1635383. Epub 2019 Jul 9. Autophagy. 2020. PMID: 31286822 Free PMC article.
Here, we aimed to define a previously unrevealed pro-fibrotic mechanism for the stress protein TRIB3 (tribbles pseudokinase 3)-mediated autophagy dysfunction. Human fibrotic liver tissues were obtained from patients with cirrhosis who underwent an open surgical repa …
Here, we aimed to define a previously unrevealed pro-fibrotic mechanism for the stress protein TRIB3 (tribbles pseudokinase 3)-mediated auto …
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-beta/Smad signaling pathway.
Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK. Mu M, et al. Drug Des Devel Ther. 2018 Dec 3;12:4107-4115. doi: 10.2147/DDDT.S186726. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 30584275 Free PMC article.
PURPOSE: Liver fibrosis is a worldwide health issue. Development of effective new drugs for treatment of this disease is of great importance. ...These findings provided evidence for potential use of ferulic acid to treat or prevent liver fibrosis....
PURPOSE: Liver fibrosis is a worldwide health issue. Development of effective new drugs for treatment of this disease is of great imp …
Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-beta/Smad and YAP signaling.
Xiang D, Zou J, Zhu X, Chen X, Luo J, Kong L, Zhang H. Xiang D, et al. Phytomedicine. 2020 Nov;78:153294. doi: 10.1016/j.phymed.2020.153294. Epub 2020 Jul 28. Phytomedicine. 2020. PMID: 32771890
BACKGROUND: Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma. ...CONCLUSION: These results clearly show that PD ameliorated experimental liver fibros …
BACKGROUND: Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of …
Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl(4): roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis.
Shu G, Yusuf A, Dai C, Sun H, Deng X. Shu G, et al. Food Funct. 2021 Nov 15;12(22):11686-11703. doi: 10.1039/d1fo02657g. Food Funct. 2021. PMID: 34730139
Herein, we assessed its effects on hepatocyte EMT and HSC activation in vitro and CCl(4)-elicited liver fibrosis in mice. Further experiments were performed to unveil the molecular mechanisms underlying the hepatoprotective activity of PIP. ...Our findings collectively sug …
Herein, we assessed its effects on hepatocyte EMT and HSC activation in vitro and CCl(4)-elicited liver fibrosis in mice. Further exp …
Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells.
Wu X, Shu L, Zhang Z, Li J, Zong J, Cheong LY, Ye D, Lam KSL, Song E, Wang C, Xu A, Hoo RLC. Wu X, et al. Adv Sci (Weinh). 2021 Jun;8(11):e2003721. doi: 10.1002/advs.202003721. Epub 2021 Mar 27. Adv Sci (Weinh). 2021. PMID: 34105268 Free PMC article.
Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease progression. ...Targeting A-FABP may represent a potential approach against liver fibrosis....
Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease prog …
Precision-Cut Liver Slices as an ex vivo model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis.
Wang Y, Leaker B, Qiao G, Sojoodi M, Eissa IR, Epstein ET, Eddy J, Dimowo O, Lauer GM, Chung RT, Qadan M, Lanuti M, Fuchs BC, Tanabe KK. Wang Y, et al. bioRxiv [Preprint]. 2023 Nov 5:2023.10.30.564772. doi: 10.1101/2023.10.30.564772. bioRxiv. 2023. PMID: 37961334 Free PMC article. Preprint.
Treatment of erlotinib, an EGFR inhibitor significantly inhibited the expression of profibrogenic genes Il6, Col1a1 and Timp1 in PCLS from CDAHFD-induced cirrhotic mice, and Il6, Col1a1 and Tgfb1 in PCLS from TAA-induced cirrhotic rats. Erlotinib treatment of PCLS from DEN …
Treatment of erlotinib, an EGFR inhibitor significantly inhibited the expression of profibrogenic genes Il6, Col1a1 and Timp1 in PCLS from C …
Liver lipopolysaccharide binding protein prevents hepatic inflammation in physiological and pathological non-obesogenic conditions.
Milbank E, Díaz-Trelles R, Dragano N, Latorre J, Mukthavaram R, Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP, Tachikawa K, Chivukula P, López M, Fernández-Real JM, Moreno-Navarrete JM. Milbank E, et al. Pharmacol Res. 2023 Jan;187:106562. doi: 10.1016/j.phrs.2022.106562. Epub 2022 Nov 21. Pharmacol Res. 2023. PMID: 36410673 Free article.
Under STD, liver Lbp gene knockdown led to a significant increase in gene expression markers of liver inflammation (Itgax, Tlr4, Ccr2, Ccl2 and Tnf), liver injury (Krt18 and Crp), fibrosis (Col4a1, Col1a2 and Tgfb1), endoplasmic reticulum (ER) stress ( …
Under STD, liver Lbp gene knockdown led to a significant increase in gene expression markers of liver inflammation (Itgax, Tlr …
Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis.
Ling L, Li G, Wang G, Meng D, Li Z, Zhang C. Ling L, et al. Mol Med Rep. 2019 Aug;20(2):1605-1612. doi: 10.3892/mmr.2019.10401. Epub 2019 Jun 20. Mol Med Rep. 2019. PMID: 31257490 Free PMC article.
The present study aimed to investigate the antifibrogenic effects of carvedilol on liver cirrhosis in vivo and in vitro. Liver cirrhosis was induced in rats by carbon tetrachloride (CCl4) administration for 9 weeks; carvedilol was administered simultan …
The present study aimed to investigate the antifibrogenic effects of carvedilol on liver cirrhosis in vivo and in vitro. Li …
Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.
Zhang Z, Yao Z, Wang L, Ding H, Shao J, Chen A, Zhang F, Zheng S. Zhang Z, et al. Autophagy. 2018;14(12):2083-2103. doi: 10.1080/15548627.2018.1503146. Epub 2018 Aug 21. Autophagy. 2018. PMID: 30081711 Free PMC article.
The internal deletion of the F3 region abrogated the ELAVL1-mediated BECN1 mRNA stability, and, in turn, prevented ELAVL1-enhanced ferroptosis. In mice, treatment with sorafenib alleviated murine liver fibrosis by inducing hepatic stellate cell (HSC) ferroptosis. ...Attrac …
The internal deletion of the F3 region abrogated the ELAVL1-mediated BECN1 mRNA stability, and, in turn, prevented ELAVL1-enhanced ferroptos …
The TGFB1 -509C/T polymorphism and elevated TGF-beta1 levels are associated with chronic hepatitis C and cirrhosis.
de Brito WB, Queiroz MAF, da Silva Graça Amoras E, Lima SS, da Silva Conde SRS, Dos Santos EJM, Cayres-Vallinoto IMV, Ishak R, Vallinoto ACR. de Brito WB, et al. Immunobiology. 2020 Sep;225(5):152002. doi: 10.1016/j.imbio.2020.152002. Epub 2020 Aug 13. Immunobiology. 2020. PMID: 32962821 Free article.
The highest TGF-beta1 levels were found in HCV-infected (p = 0.0329) individuals and in TT genotype carriers. Patients with cirrhosis had higher TGF-beta1 (p = 0.0400). IFN-gamma and TGF-beta1 levels showed a negative correlation (p = 0.0001). In conclusion, the TGFB1 …
The highest TGF-beta1 levels were found in HCV-infected (p = 0.0329) individuals and in TT genotype carriers. Patients with cirrhosis …
443 results